Novel putative protein tyrosine phosphatases identified by the polymerase chain reaction
Open Access
- 1 October 1990
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 271 (1-2), 178-180
- https://doi.org/10.1016/0014-5793(90)80400-d
Abstract
Protein tyrosine phosphatases (PTPases) are a family of enzymes that specifically dephosphorylate phosphotyrosyl residues in selected protein substrates. To more fully understand the regulatory role of protein tyrosine phosphorylation and dephosphorylation in cellular signal transduction, characterization of PTPases is essential. Using the polymerase chain reaction and degenerate oligonucleotide primers corresponding to conserved amino acid sequences within the catalytic domain of PTPases, we have identified 11 PTPase‐related human liver cDNA sequences. Five of these have not been described previously. These results indicate that, like protein tyrosine kinases. PTPases may also comprise a gene family with a large number of members.Keywords
This publication has 18 references indexed in Scilit:
- Expression of voltage-gated K+ channels in insulin-producing cellsFEBS Letters, 1990
- Protein tyrosine dephosphorylation and signal transductionTrends in Biochemical Sciences, 1989
- Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines.Proceedings of the National Academy of Sciences, 1989
- A family of receptor-linked protein tyrosine phosphatases in humans and Drosophila.Proceedings of the National Academy of Sciences, 1989
- Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase.Proceedings of the National Academy of Sciences, 1989
- cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family.Proceedings of the National Academy of Sciences, 1989
- Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins.Proceedings of the National Academy of Sciences, 1989
- Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction.Proceedings of the National Academy of Sciences, 1989
- A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen.The Journal of Experimental Medicine, 1988
- GROWTH FACTOR RECEPTOR TYROSINE KINASESAnnual Review of Biochemistry, 1988