Reliability of the family history method in genetic studies of Alzheimer's disease and related dementias
- 1 October 1986
- journal article
- research article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 143 (10), 1279-1282
- https://doi.org/10.1176/ajp.143.10.1279
Abstract
The investigation of genetic and other causes of Alzheimer''s disease requires reliable and valid methods of gathering historical data on elderly relatives. To assess the reliability of the family history method in the study of late-onset dementing illness, the authors studied families with Alzheimer''s disease probands and control families. The results indicated that family history data obtained from multiple informants with standardized instruments are consistent across informants. The rate of Alzheimer''s disease in the families studied was similar to rates found in previous studies.This publication has 9 references indexed in Scilit:
- Familial aggregation in Alzheimer dementia—II. Clinical genetic implications of age-dependent onsetJournal of Psychiatric Research, 1986
- Familial aggregation in Alzheimer dementia—I. A model for the age-dependent expression of an autosomal dominant geneJournal of Psychiatric Research, 1986
- A new rating scale for Alzheimer's diseaseAmerican Journal of Psychiatry, 1984
- Clinical diagnosis of Alzheimer's diseaseNeurology, 1984
- Information From RelativesArchives of General Psychiatry, 1984
- Familial Alzheimer Dementia: a prevalent disorder with specific clinical featuresPsychological Medicine, 1984
- Alzheimer's disease: Genetic aspects and associated clinical disordersAnnals of Neurology, 1983
- Dementia of the Alzheimer TypeArchives of General Psychiatry, 1981
- The Family History Method Using Diagnostic CriteriaArchives of General Psychiatry, 1977