THE TRIMETHYLTIN SYNDROME IN RATS
- 1 January 1982
- journal article
- research article
- Vol. 4 (2), 127-133
Abstract
Trimethyltin (TMT) chloride, administered to adult male Long-Evans hooded rats, produced a unique and distinctive behavioral syndrome consisting of spontaneous seizures, tail mutilation; vocalization and hyperreactivity. The LD50 for TMT was weight dependent; in large rats (450 g), 7 mg/kg TMT produced significant weight loss and lethality; in small rats (250 g), 7 mg/kg produced no weight loss or lethality. TMT produced mild hypothermia and tremors. Results were discussed in comparison with kainic acid-induced morphological alterations and septal lesion-induced behavioral alterations. Histopathological evaluations of hippocampal tissue revealed cell loss that has largely confined to regio inferior pyramidal cells. TMT has potential as a tool for investigations of limbic system structure and function.This publication has 9 references indexed in Scilit:
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