Calmodulin-dependent Ca2+ transport in erythrocytes of spontaneously hypertensive rats

Abstract

Ca²⁺ transport in inside-out vesicles of the erythrocyte membranes of spontaneously hypertensive rats (SHR) was studied. In the presence of calmodulin, the rate of⁴⁵Ca uptake by the erythrocyte membranes of SHR was half that of erythrocyte membranes of the normotensive control group. It is suggested that the decrease of the rate of calmodulin-dependent calcium transport across the plasma membrane may be a cause for the increased intracellular calcium content found in some tissues of spontaneously hypertensive rats in previous studies.