A High-Performance Nanobio Photocatalyst for Targeted Brain Cancer Therapy
- 29 July 2009
- journal article
- letter
- Published by American Chemical Society (ACS) in Nano Letters
- Vol. 9 (9), 3337-3342
- https://doi.org/10.1021/nl901610f
Abstract
We report pronounced and specific antiglioblastoma cell phototoxicity of 5 nm TiO2 particles covalently tethered to an antibody via a dihydroxybenzene bivalent linker. The linker application enables absorption of a visible part of the solar spectrum by the nanobio hybrid. The phototoxicity is mediated by reactive oxygen species (ROS) that initiate programmed death of the cancer cell. Synchrotron X-ray fluorescence microscopy (XFM) was applied for direct visualization of the nanobioconjugate distribution through a single brain cancer cell at the submicrometer scale.Keywords
This publication has 55 references indexed in Scilit:
- Small Solutions for Big Problems: The Application of Nanoparticles to Brain Tumor Diagnosis and TherapyClinical Pharmacology & Therapeutics, 2009
- The Antibacterial Effects of Biphasic Brookite-Anatase Titanium Dioxide Nanoparticles on Multiple-Drug-Resistant Staphylococcus aureusJournal of Biomedical Nanotechnology, 2008
- X-ray fluorescence microscopy reveals large-scale relocalization and extracellular translocation of cellular copper during angiogenesisProceedings of the National Academy of Sciences, 2007
- Symposium‐in‐Print: Singlet Oxygen Invited ReviewPhotochemistry and Photobiology, 2006
- Studies on photokilling of bacteria on TiO2 thin filmJournal of Photochemistry and Photobiology A: Chemistry, 2003
- Photoinduced bactericidal activity againstPseudomonas aeruginosaby TiO2based thin filmsFEMS Microbiology Letters, 2002
- Disinfection of E. coli by the Ag-TiO 2 /UV system: lipidperoxidationJournal of Photochemistry and Photobiology A: Chemistry, 2001
- An overview of semiconductor photocatalysisJournal of Photochemistry and Photobiology A: Chemistry, 1997
- Intracellular Ca2+ concentration change of T24 cell under irradiation in the presence of TiO2 ultrafine particlesBiochimica et Biophysica Acta (BBA) - General Subjects, 1994
- Photokilling of Malignant Cells with Ultrafine TiO2 PowderBulletin of the Chemical Society of Japan, 1991