Minocycline hydrochloride treatment for atypical acid-fast infection

Abstract

Atypical acid-fast infections [Mycobacterium marinum] are not infrequent in the Gulf Coastal region. The development of erythematous papules within 3 or 4 wk after aquatic exposure deserves such consideration. Deeper tissues may also become involved. This should signal a caution when considering the use of corticosteroid injections in such a suspicious lesion. Inasmuch as hypertrophic scar formation at a site of trauma must be considered in the differential diagnosis, it is important to secure histopathologic examination prior to treatment. While a surgical approach was required for the most part, oral administration of minocycline hydrochloride brought about healing in the patients reported herein. This article deals with only 3 cases. The response was complete and without recurrence in each. Such therapy is recommended prior to the use of more drastic procedures.