Acute Experimental Canine Ehrlichiosis
- 1 January 1981
- journal article
- Published by SAGE Publications in Veterinary Pathology
- Vol. 18 (1), 48-61
- https://doi.org/10.1177/030098588101800106
Abstract
Dogs with acute Ehrlichia canis infection showed the established clinical features of acute ehrlichiosis and had thrombocytopenia, anemia, increased serum glutamic pyruvic transaminase activity, and decreased total serum protein and albumin concentrations during the first weeks after infection, and increasing gamma globulin concentrations after the third week. Gross lesions in hemic and lymphoreticular tissues were transient lymphadenomegaly, splenomegaly, and increased red long-bone marrow. Lymphoreticular hyperplasia in the paracortical area of lymph nodes and in the splenic red pulp occurred during the second week of infection. Later, small lymphocytes were replaced by medium-sized lymphocytes and plasma cells. Activity of germinal centers increased initially, as shown by numerous mitotic figures and macrophages, but diminished later, and the follicles blended with interfollicular and paracortical tissue because of a decrease in small lymphocytes in the mantle layer. We saw splenic hemorrhages near the perifollicular sinus, and vasculitis, most often phlebitis, in the kidney between weeks 2 and 4. Multifocal reticuloendothelial hyperplasia occurred in the liver during the early stage and injured adjacent hepatocytes by compression. Lesions typical of ehrlichiosis in these dogs were interstitial pneumonia, subendothelial aggregates of mononuclear cells in pulmonary blood vessels, renal periglomerular and perivenular plasmacytosis, hemopoietic hyperplasia, and perivascular cuffs of lymphocytes and plasma cells in many organs.Keywords
This publication has 21 references indexed in Scilit:
- Tropical canine pancytopenia: Role of aplastic anaemia in the pathogenesis of severe diseaseJournal of Comparative Pathology, 1975
- Tropical Canine Pancytopenia: Clinical, Hematologic, and Serologic Response of Dogs to Ehrlichia canis Infection, Tetracycline Therapy, and Challenge InoculationThe Journal of Infectious Diseases, 1974
- Lymphoreticular Lesions of Canine NeorickettsiosisThe Journal of Infectious Diseases, 1974
- The pathogenesis of the vascular lesions in experimental rickettsial disease of the guinea pig (Rocky Mountain Spotted fever group)Virchows Archiv, 1973
- Lymphocytes and the Immune ResponseNew England Journal of Medicine, 1971
- Lymphocytes and the Immune ResponseNew England Journal of Medicine, 1971
- Pathological effects of Trypanosoma brucei on small blood vessels in rabbit ear-chambersTransactions of the Royal Society of Tropical Medicine and Hygiene, 1971
- Pooling of platelets in the spleen: role in the pathogenesis of "hypersplenic" thrombocytopenia.JCI Insight, 1966
- The identification of platelets and platelet antigens in histological sectionsThe Journal of Pathology and Bacteriology, 1965
- Blood Changes Associated with Disseminated TuberculosisBMJ, 1954