CHROMOSOME CHANGES IN EARLY GYNECOLOGIC MALIGNANCIES

Abstract

Chromosome changes characteristic of fully invasive neoplasms were found in direct preparations from a noninvasive ovarian carcinoma and 3 carcinomas in situ of the cervix uteri, 2 of which showed early stromal invasion. Abnormal chromosomes present included structurally changed chromosomes 6 and an isochromosome for the long arm of chromosome 17 (in the ovarian carcinoma and 1 carcinoma in situ), chromosomes 1 with long arm deletions (in 2 carcinomas in situ) and double minute chromatin bodies (in 1 of 2 metaphases obtained from the 3rd carcinoma in situ). A chromosome of uncertain origin with a homogeneously staining region was also present in the ovarian carcinoma.