Progeria

Abstract

SINCE the original description of cases of progeria by Hutchinson¹ in 1886 and Gilford² in 1897 only 22 such cases have been reported. Children with this syndrome show a striking resemblance to each other. They appear normal at birth, dwarfism being noted within the first few years of life. Associated with dwarfism is a typical facies with a beaklike nose, a relatively small face with receding chin, exophthalmos, loss of hair, prominent scalp veins, markedly diminished subcutaneous fat, muscular atrophy, arthritic joint deformities, shortened clavicles, coxa valga, a "horse-riding" stance, arteriosclerosis and normal or above normal intelligence for the patient's . . .