Relationship between partition coefficients and apparent volumes of distribution for basic drugs. I.

Abstract

The model was proposed to relate the apparent volume of distribution (Vd'') of a drug to the apparent partition coefficient (P'') and the volume of blood plasma. Vd'' values for basic drugs were almost constant in the region of low P'' and Vd'' increases in the region of high P''. The average Vd'' value (1.47 l/kg) for basic drugs with low P'' was about 30 times larger than the value of the blood plasma volume (0.05 l/kg).