Single-Dose Therapy of Chancroid with Trimethoprim–Sulfametrole
- 14 July 1983
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 309 (2), 67-71
- https://doi.org/10.1056/nejm198307143090202
Abstract
We conducted a randomized double-blind trial comparing a single dose of trimethoprim–sulfametrole (640 to 3200 mg) with five-day regimens of either trimethoprim–sulfametrole (160 to 800 mg twice daily) or trimethoprim alone (200 mg twice daily) for the treatment of men with chancroid. Of 95 patients, 78 had cultures positive for Hemophilus ducreyi. Twenty-seven, 23, and 28 patients, respectively, were assigned to the single-dose trimethoprim–sulfametrole, the five-day trimethoprim–sulfametrole, and the five-day trimethoprim treatments. The rate of ulcer and bubo resolution, the mean (±S.D.) healing times (10.3±5.7, 11.0±7.4, and 11.9±8.2 days, respectively), the microbiologic response, the number of treatment failures, and the number of recurrent ulcers were similar in all three treatment groups. We conclude that single-dose trimethoprim–sulfametrole is a highly effective, inexpensive therapy for chancroid in men and may prove to be an important strategy for the control of H. ducreyi infection. (N Engl J Med 1983; 309:67–71.)This publication has 12 references indexed in Scilit:
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