Gonadotropin Therapy

Abstract

The individual patient response to menotropins therapy was found to be extremely variable. Failure to appreciate this variability can lead to ovarian overstimulation. Overstimulation was found to be associated with abnormally high excretion levels of total estrogen. The author concluded that daily monitoring of estrogen excretion by a rapid chemical method was necessary to determine the optimum time for the administration of chorionic gonadotropin and, at the present time, provided the best method for preventing ovarian overstimulation.