Identification of (1S)-phosphoryloxy-(2R,4S)-dihydroxycyclohexane as a potent inhibitor of inositol monophosphatase

Abstract

The 3,5,6-trisdeoxy derivative of myo-Inositol 1-monophosphate, (1S)-phosphoryloxy-(2R,4S)-dihydroxycyclohexane [(–)-(1)], derived from the parent substrate by a strategy of hydroxy deletion, has been synthesised and shown to be the most potent inhibitor of Inositol monophosphatase yet identified.