A behavioral and pharmacological analysis of variables mediating active-avoidance behavior in rats.

Abstract

In Exp. I, two strains of rats (F344 and ZM) were run in a discriminated -maze avoidance task. The F344s were greatly superior to ZMs in acquiring the avoidance response although both strains learned the discrimination. Analysis of other response measures indicates that F344s made significantly more active responses, suggesting that differences in avoidance behavior were due to strain-specific differences in the unconditioned response to shock. In Exp. II, the same Ss were administered d-amphetamine, scopolamine, or a combination of the 2 drugs. These manipulations significantly improved avoidance behavior in the ZM strain and increased other active responses. Results suggest that the prepotent variable in active-avoidance acquisition is the extent to which the S's response to shock is compatible with the response required. (23 ref.) (PsycINFO Database Record (c) 2006 APA, all rights reserved)