THE EFFECT OF MEPROBAMATE ON THE ELECTROENCEPHALOGRAM1,2

Abstract

We have repeatedly noted a clear increase in rhythmic fast activity in patients on meprobamate, the changes being more pronounced with higher doses of the drug. Fifty uncomplicated cases showed excess fast activity in 86% of the eeg''s. Another group of 50 cases contaminated by other drugs had an incidence of 84%. Ten of 12 cases receiving a single acute dose by mouth showed increased fast activity. This effect, which resembles that seen with barbiturates, thus represents an important variable in clinical electroencephalography.