The differentiation of true and pseudo cholinesterase by organo-phosphorus compounds
- 1 January 1953
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 53 (1), 62-67
- https://doi.org/10.1042/bj0530062
Abstract
Eleven inhibitors were tested with cholinesterases of bloods of horse, man, guinea pig, dog, rat, and sheep on acetyl-, propionyl-, n-butyryl-, isobutyryl-, n-valeryl, isovaleryl-, benzoyl-and acetyl-beta-methyl-choline. Based on the effect of changes of acyl groups in choline esters on their hydrolysis by true and pseudo cholinesterase an explanation of the different sensitivities of the 2 enzymes for organo-phosphorus inhibitors was suggested.Keywords
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