THE ACTION OF OVARY-STIMULATING SUBSTANCE OF HUMAN URINE OF PREGNANCY ON UTERINE MOTILITY IN THE UNANESTHETIZED RABBIT

Abstract

[long dash]The uterine response to doses, subminimal for ovulation, of the ovary-stimulating substance of human urine was observed in 8 unanesthetized rabbits (16 experiments). As little as 0.05 cc. induced a transitory decrease in uterine motility in 6-8 hrs. In the presence of the ovary only excessive follicular growth results from such a small dosage of the urine-substance; larger amounts (0.4-1 cc.) induce lasting uterine quiescence and, at the same time, ovulation. In 6 of 10 experiments on 8 castrated rabbits stimulated to uterine activity by theelin, the same amt. of pregnancy urine substance almost completely (but temporarily) suppressed uterine motility; in 2 others, motility was decreased. One may conclude that the effect of the urine-substance is independent of the ovary, yet when this organ is present it probably contributes to the effect.