Gene with Quantitative Effect on Circulating Interferon Induced by Newcastle Disease Virus

Abstract

Circulating interferon production, induced by Newcastle disease virus, is about seven times higher in C₅₇ Black mice than i Balb/c/Gif mice. A Mendelian analysis was carried out and circulating interferon production was measured in reciprocal F₁ hybrids, in the F₂ generation, in progeny of backcrosses of F₁ hybrids to either parent strain, and in second backcross progeny. The results indicate that a single, partly dominant, autosomal factor is responsible for the difference in circulating interferon production between both parent strains.