Synthesis of cis- and trans-tamoxifen
- 1 July 1987
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 17 (10), 1247-1251
- https://doi.org/10.1080/00397918708063976
Abstract
The synthesis of cis-tamoxifen, non antiestrogenic tetrasubstituted olefin, was achieved via carboalumination of diphenylacetylene as a key step. Conversion to the antiestrogenic trans-tamoxifen was achieved by facile cis-trans isomerization of the corresponding phenol by acid or catalysts.Keywords
This publication has 5 references indexed in Scilit:
- Stereospecific synthesis of (Z)-tamoxifen via carbometallation of alkynylsilanesThe Journal of Organic Chemistry, 1985
- A highly stereoselective synthesis of 1-halo-1-(trimethylsilyl)-2,2-dialkyl olefinsThe Journal of Organic Chemistry, 1984
- Synthesis of the (E) and (Z) isomers of the antiestrogen tamoxifen and its metabolite, hydroxytamoxifen, in tritium-labeled formThe Journal of Organic Chemistry, 1982
- TamoxifenDrugs, 1978
- Preparation and Identification of cis and trans Isomers of a Substituted TriarylethyleneNature, 1966