• Adverse reactions seen after the administration of the tranquilizing drug meprobamate included cutaneous, muscular, gastrointestinal, and paradoxical cerebral effects. The cutaneous effects, seen in five cases, were chiefly purpuric and accompanied by intense itching; one 400-mg. tablet of meprobamate sufficed to produce the skin lesions without previous exposure. Temporary palsy of extraocular muscles produced diplopia in one case; severe diarrhea occurred in another. Paradoxical cerebral reaactions in the form of extreme excitement were seen in three cases. The seven case histories here given illustrate the intensity and reproducibility of these reactions. All patients recovered after the drug was withdrawn; recovery was hastened by the use of antihistaminics, corticotropin, topical applications, and colloidal baths.