Transition-Metal-Catalyzed Carbon-Carbon Bond Formation via Carbon-Hydrogen Bond Cleavage

Abstract

Catalytic functionalization of unreactive C-H bond has become one of the most attractive research subjects in modern organic chemistry. To date, a variety of catalytic reactions involving C-H bond cleavage have been reported. In this review, we briefly survey the reported research with respect to efficient and selective transition-metal-catalyzed C-C bond formation via C-H bond cleavage. 1 Introduction 2 Addition of C-H Bonds to C-C Multiple Bonds 3 Alkenylation of C-H Bonds via Substitution Reactions 4 Carbonylation and Acylation of C-H Bonds Using Carbon Monoxide 5 Arylation of C-H Bonds 6 Sequential Coupling of Aryl Halides with Alkyl Halides Using Norbornene as a Mediator 7 Conversion of C-H Bonds into C-C Bonds via 1,4- and 1,5-Transition-Metal Migrations 8 Addition of C-H Bonds to Polar C=X Bonds 9 Conclusions