Pancytopenia with Hyperplastic Marrow

Abstract

The purpose of this paper is to report a patient with pancytopenia in the presence of hyperplastic bone marrow with a maturation arrest of the erythrocytic and granulocytic elements, and in whom treatment with testosterone was associated with a complete remission of her pancytopenia. She also exhibited multiple congenital anomalies of the type described in cases of "Fanconi's hypoplastic anemia."^1-2 Report of Case The patient was a Caucasian girl, first seen in April, 1954, at the age of 11 years, with the history of frequent spontaneous epistaxis, easy bruising, and increasing fatigability for a period of several years. Unfortunately, the exact age of onset of symptoms was not available; however, the patient apparently had her first severe nose bleed at age 7 years according to institution records. She was a ward of the state, and details of gestation, birth, and early development were unavailable. The patient had had chickenpox,