Vibralactone: A Lipase Inhibitor with an Unusual Fused β-Lactone Produced by Cultures of the Basidiomycete Boreostereum vibrans
- 16 November 2006
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 8 (25), 5749-5752
- https://doi.org/10.1021/ol062307u
Abstract
The structure and absolute configuration of vibralactone (1) from the cultures of the Basidiomycete Boreostereum vibrans were established by spectroscopic methods and computational methods. Vibralactone, an unusual fused β-lactone-type metabolite, was found to inhibit pancreatic lipase with an IC50 of 0.4 μg/mL.Keywords
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