HEPATIC DAMAGE ASSOCIATED WITH SULFONAMIDE THERAPY IN INFANTS AND CHILDREN. II. CHANGES IN LIVER FUNCTION TEST DURING SULFONAMIDE THERAPY

Abstract

The liver function of 73 children was followed by means of the colloidal Au test of Gray during treatment with sulfathiazole or sulfadiazine. The initial negative reaction changed to a marked positive in 13 children and to a slight positive in 11 children after 3-23 days of therapy. The changes could not be correlated with the amt. or duration of therapy. Forty-nine children showed no alteration in the colloidal Au reaction in from 3-42 days of therapy. Necropsy findings in 4 cases are included.