Insulinanaloga durch Austausch von Al-Glycin gegen D-Aminosäuren und ω-Aminosäuren

Abstract

Substitution of A1-Gly of insulin by L-amino acids yields analogs with low biological activity. With D-amino acids in A1 biological activity is essentially retained. The influence of aliphatic, aromatic, acidic and basic .alpha.-D-amino acids as well as .omega.-amino acids in A1 on the biological effects in different test systems [fat cell assay, rat diaphragm] is studied and discussed.