Alternative multidrug regimen provides improved suppression of HIV-1 replication over triple therapy

Abstract

To compare the viral suppression of two antiretroviral regimens using three drugs or five drugs. Two open-label studies using a three-drug (zidovudine, lamivudine and ritonavir) and a five-drug regimen (zidovudine, lamivudine, abacavir, indinavir and nevirapine) in study-drug-naive patients, except for one in the five-drug study. Participants with ≥ 10 000 HIV-1 RNA copies/ml in plasma at baseline were compared by means of Kaplan-Meier curves for time to The elimination rate constants for HIV-1 RNA in 15 participants of the three-drug study were compared with nine participants of the five-drug study. The level of P With the five drugs used in this study, the median time to reach