THE BRITISH FORM OF HEREDITARY PERSISTENCE OF FETAL HEMOGLOBIN RESULTS FROM A SINGLE BASE MUTATION ADJACENT TO AN S1-HYPERSENSITIVE SITE 5' TO THE A-GAMMA-GLOBIN GENE
- 1 December 1986
- journal article
- research article
- Vol. 68 (6), 1389-1393
Abstract
The G.gamma. and A.gamma. genes of an individual homozygous for the British form of A.gamma. nondeletion hereditary persistence of fetal hemoglobin have been cloned and partially sequenced. The G.gamma. gene was normal, but the A.gamma. gene was found to have a single base change (T .fwdarw. C) at - 198 bp relative to the cap site. Supercoiled plasmids containing normal .gamma.-genes or the mutant A.gamma.-gene displayed an S1-hypersensitive site immediately 5'' to the base change.This publication has 20 references indexed in Scilit:
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