A Comparative Study of 470 Cases of Early-Onset and Late-Onset Schizophrenia
- 1 September 1993
- journal article
- Published by Royal College of Psychiatrists in The British Journal of Psychiatry
- Vol. 163 (3), 352-357
- https://doi.org/10.1192/bjp.163.3.352
Abstract
The presence or absence of 22 schizophrenic symptoms was recorded with the age at onset of illness in 470 patients with non-affective, non-organic psychoses. Positive and negative formal thought disorder, affective symptoms, inappropriate affect, delusions of grandiosity or passivity, primary delusions other than delusional perception, and thought insertion and withdrawal were all more common in early-onset cases (age at onset 44 years or less;n= 336). Persecutory delusions with and without hallucinations, organised delusions, and third-person, running commentary and accusatory or abusive auditory hallucinations were all more common in late-onset cases (age at onset 45 years or more;n= 134). There was no difference between cases of early and late onset in the prevalence of delusions of reference, bizarre delusions, delusional perception, or lack of insight. We conclude that although there are clinical similarities between cases of schizophrenia with early and late onset, there are sufficient differences between them to suggest that they are not phenotypically homogeneous.Keywords
This publication has 25 references indexed in Scilit:
- Sex and Schizophrenia: Effects of Diagnostic Stringency, and Associations with Premorbid VariablesThe British Journal of Psychiatry, 1993
- The Incidence of Operationally Defined Schizophrenia in Camberwell, 1965–84The British Journal of Psychiatry, 1991
- Brain White-Matter Lesions and PsychosisThe British Journal of Psychiatry, 1989
- Late Paraphrenia or the Paraphrenias?The British Journal of Psychiatry, 1987
- Late paraphrenia: Neuropsychological impairment and structural brain abnormalities on computed tomographyInternational Journal of Geriatric Psychiatry, 1987
- Schizophrenia in Old Age (Late Paraphrenia)The British Journal of Psychiatry, 1984
- Late ParaphreniaThe British Journal of Psychiatry, 1967
- Environmental and Hereditary Factors in the Schizophrenias of Old Age (“Late Paraphrenia”) and their Bearing on the General Problem of Causation in SchizophreniaJournal of Mental Science, 1961
- Senile SchizophreniaJournal of Mental Science, 1960
- The Natural History of Mental Disorder in Old AgeJournal of Mental Science, 1955