Structure and antitumor activity of a .BETA.-1,3-glucan isolated from the culture filtrate of Sclerotinia sclerotiorum IFO 9395.
- 1 January 1986
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 34 (3), 1362-1365
- https://doi.org/10.1248/cpb.34.1362
Abstract
An antitumor glucan (SSG) was isolated from the culture filtrate of Sclerotinia sclerotiorum IFO 9395 by sequential use of ethanol precipitation, ion exchange chromatography on diethylaminoethyl-Sephadex A-25, and precipitation with ammonium sulfate. From the results of methylation analysis and carbon-13 nuclear magnetic resonance spectroscopy, SSG was concluded to be a .beta.-1,3-D-glucan branched at position 6 of every two 3-substituted .beta.-glucosyl units. SSG formed a complex with congo red in dilute alkali solution, and showed potent antitumor activity against the solid form of sarcoma 180 in ICR mice.This publication has 7 references indexed in Scilit:
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