MD-2 binds to bacterial lipopolysaccharide
Open Access
- 1 December 2000
- journal article
- other
- Published by SAGE Publications in Innate Immunity
- Vol. 6 (6), 489-491
- https://doi.org/10.1177/09680519000060060201
Abstract
Many LPS binding proteins have been described, but the exact nature of the LPS receptors that signal cells remains unclear. MD-2 is a molecule that is found in association with Toll-like receptor 4, which has been shown to be a receptor for LPS. We have produced human MD-2 in baculovirus and tested it for LPS binding. MD-2 binds the lipid A region of LPS without the need for LPS binding protein. These data suggest that MD-2 may be binding LPS as part of the TLR4 receptor complex.Keywords
This publication has 8 references indexed in Scilit:
- Soluble CD14 Enhances Membrane CD14-Mediated Responses to Peptidoglycan: Structural Requirements Differ from Those for Responses to LipopolysaccharideInfection and Immunity, 2000
- Structure-Function Analysis of CD14 as a Soluble Receptor for LipopolysaccharidePublished by Elsevier ,2000
- MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4The Journal of Experimental Medicine, 1999
- Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal TransductionJournal of Biological Chemistry, 1999
- Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 GeneScience, 1998
- Lipopolysaccharide Binding Protein-mediated Complexation of Lipopolysaccharide with Soluble CD14Journal of Biological Chemistry, 1995
- CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding ProteinScience, 1990
- Identification of lipopolysaccharide-binding proteins in 70Z/3 cells by photoaffinity cross-linking.Journal of Biological Chemistry, 1990