Skin prick test in the diagnosis of dog dander allergy A comparison of different extracts with clinical history, provocation tests and RAST

Abstract

Skin prick tests (SPT), were carried out on 164 asthmatic children using dog dander allergen preparations (A, B1, B2 and D) from 3 manufacturers. Bronchial and/or conjunctival provocation tests with allergen A were performed on all patients, as well as the Phadebas RAST [radioallergosorbent test] (allergen e5). There was a close agreement between the clinical history and the SPT with allergens A and D. The provocation tests and RAST gave results in good agreement with the SPT reactions to all allergens except B1. The overall agreement between the SPT reactions to the different allergens was good. Significant differences were observed in the allergenic activity of the different preparations and between different batches from the same manufacturer (allergens B1 and B2).