Avian Influenza Virus (H5N1): a Threat to Human Health
Top Cited Papers
- 1 April 2007
- journal article
- review article
- Published by American Society for Microbiology in Clinical Microbiology Reviews
- Vol. 20 (2), 243-267
- https://doi.org/10.1128/cmr.00037-06
Abstract
Pandemic influenza virus has its origins in avian influenza viruses. The highly pathogenic avian influenza virus subtype H5N1 is already panzootic in poultry, with attendant economic consequences. It continues to cross species barriers to infect humans and other mammals, often with fatal outcomes. Therefore, H5N1 virus has rightly received attention as a potential pandemic threat. However, it is noted that the pandemics of 1957 and 1968 did not arise from highly pathogenic influenza viruses, and the next pandemic may well arise from a low-pathogenicity virus. The rationale for particular concern about an H5N1 pandemic is not its inevitability but its potential severity. An H5N1 pandemic is an event of low probability but one of high human health impact and poses a predicament for public health. Here, we review the ecology and evolution of highly pathogenic avian influenza H5N1 viruses, assess the pandemic risk, and address aspects of human H5N1 disease in relation to its epidemiology, clinical presentation, pathogenesis, diagnosis, and management.Keywords
This publication has 272 references indexed in Scilit:
- Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptorsNature, 2006
- Glycan microarray technologies: tools to survey host specificity of influenza virusesNature Reviews Microbiology, 2006
- Protective avian influenza in ovo vaccination with non-replicating human adenovirus vectorVaccine, 2006
- Strategies for mitigating an influenza pandemicNature, 2006
- Was the 1918 pandemic caused by a bird flu?Nature, 2006
- Avian Influenza A (H5N1) Infection in HumansNew England Journal of Medicine, 2005
- Detection of anti-H5 responses in human sera by HI using horse erythrocytes following MF59-adjuvanted influenza A/Duck/Singapore/97 vaccineVirus Research, 2004
- Differences between influenza virus receptors on target cells of duck and chickenArchiv für die gesamte Virusforschung, 2002
- Replication of avian influenza viruses in humansArchiv für die gesamte Virusforschung, 1991
- Conjunctivitis in Human Beings Caused by Influenza A Virus of SealsNew England Journal of Medicine, 1981