The effect of dinitro-o-cresol on the deposition of liver glycogen in the rat

Abstract

Single and repeated toxic doses of dinitro-o-cresol (DNOC) in the rat induce an initial fall in liver glycogen which is followed by a progressive rise. After 24 hrs. the level is higher in control animals. A single dose of DNOC does not impair the absorption of glucose or laying down of glycogen in fasting rats. Blood lactic acid levels are not affected by the doses of DNOC given. Repeated doses of DNOC increased the wt. of the male adrenal, but not that in the female rat. Changes in liver glycogen are taken to be a reflection of the general metabolic disturbance produced by DNOC. The level of liver glycogen in a normal rat fasted for 24 hrs. depends upon the feeding habits to which the animals are accustomed before the fast.