Some things have to be discovered twice. Such is the case with the use of aminophylline in treating apnea. Vogi first described the use of aminophylline for the treatment of Cheyne-Stokes respiration in 1927.1 His observations were amply confirmed2,3 but no interest in this therapy occured in pediatrics. Kuzemko and associates first introduced rectally administered aminophylline as a treatment for apnea of prematurity in 1973.4-5 This publication initially attracted little attention. Bednarek and Roloff6 and others have confirmed Kuzemko's findings (J.F. Lucey, unpublished data). Shannon et at.7 introduced the use of orally administered theophylline and their successful results have also been confirmed.8