Intact human erythrocytes prevent hydrogen peroxide-mediated damage to isolated perfused rat lungs and cultured bovine pulmonary artery endothelial cells.
Open Access
- 1 July 1984
- journal article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 74 (1), 292-295
- https://doi.org/10.1172/jci111414
Abstract
Addition of untreated or glutaraldehyde-fixed human erythrocytes decreased hydrogen peroxide (H2O2)-mediated acute edematous injury in isolated rat lungs, H2O2-induced damage to cultured bovine pulmonary artery endothelial cells, and H2O2-dependent oxidation of reduced cytochrome C in vitro. The results suggest that intact erythrocytes can scavenge H2O2, and as a result, protect the lung and possibly other tissues from damage.This publication has 16 references indexed in Scilit:
- State of the ArtAmerican Review of Respiratory Disease, 1983
- Neutrophil-mediated methemoglobin formation in the erythrocyte. The role of superoxide and hydrogen peroxide.Journal of Biological Chemistry, 1982
- OXYGEN-RADICAL-MEDIATED PERMEABILITY EDEMA AND VASOCONSTRICTION IN ISOLATED PERFUSED RABBIT LUNGSPublished by Elsevier ,1982
- Effects of Superoxide on the Erythrocyte MembraneJournal of Biological Chemistry, 1978
- FINE-STRUCTURAL ALTERATIONS INDUCED IN ERYTHOCYTES BY PHORBOL MYRISTATE ACETATE1978
- In vivo inhibition of superoxide dismutase in mice by diethyldithiocarbamate.Journal of Biological Chemistry, 1976
- Venous endothelial damage produced by massive sticking and emigration of leukocytes.1974
- Catalase Activity and Red Cell MetabolismPublished by Springer Nature ,1972
- STUDIES ON QUANTITATIVE AND QUALITATIVE CHARACTERIZATION OF ERYTHROCYTE GLUTATHIONE PEROXIDASE1967
- Generation of Hydrogen Peroxide in Erythrocytes by Hemolytic Agents*Biochemistry, 1964