IMMUNOGENICITY OF SERUM HLA ANTIGENS IN ALLOGENEIC COMBINATIONS

Abstract
Immunization of patients with chronic renal insufficiency with plasma from selected donors elicited lymphocytotoxic antibodies. Analysis of these antibodies with Fab2 blocking assays showed that they are directed to HLA-A,B and to Ia-like antigens. Serum HLA antigens are apparently immunogenic in allogeneic combinations.