Effects of Long-term Vitamin E Supplementation on Cardiovascular Events and Cancer
Top Cited Papers
Open Access
- 16 March 2005
- journal article
- clinical trial
- Published by American Medical Association (AMA) in JAMA
- Vol. 293 (11), 1338-1347
- https://doi.org/10.1001/jama.293.11.1338
Abstract
Oxidative injury has been implicated in atherosclerotic cardiovascular disease and in cancer, the 2 leading causes of death. Low-density lipoprotein cholesterol is rendered more atherogenic by oxidative modification1 and many carcinogens create free oxygen radicals that damage DNA and other cellular structures, initiating and promoting tumor development.2 Therefore, antioxidant vitamins have been extensively evaluated in the prevention of cardiovascular diseases and cancer.Keywords
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