THE DEPRESSOR EFFECT OF SPLENO-RENO-PEXY ON HYPERTENSION DUE TO RENAL ISCHEMIA

Abstract

Dogs were rendered hypertensive by the Goldblatt method. One to 2 mos. later pexis of the spleen with one ischemic kidney lowered the blood pressure to normal prehypertensive levels in each of 9 instances. This lowered blood pressure persisted throughout the 2-10 mo. periods of observation. Removal of the fused kidney and spleen resulted in the return of hypertension in the 3 animals that survived the operation for more than 3 days. Two of the 3 dogs maintained the hypertension that followed the removal of the fused organs for the 6 mos. that they were studied. India ink injected into the splenic arteries of the excised fused spleen and kidney showed that collateral circulation from the spleen went to the capillaries of the renal convoluted and collecting tubules. The observations indicate that this collateral circulation to one ischemic kidney neutralizes the pressor action of not only that kidney but also of the other ischemic kidney.