Effect of Low Molecular Weight Dextran on Gastric Ulceration and Gastric Secretion in Pylorus-Ligated Rats

Abstract

The effects of low molecular weight dextran on gastric ulcer and gastric secretion was evaluated in pylorus ligated rats. Incidence and severity of ulceration was markedly reduced. Acid output was decreased by 85% and pepsin output by 70%. The effect on ulceration is probably related to the decreased acid output rather than to any improvement in tissue blood flow. Low molecular weight dextran may exert its effect by inhibiting histamine release.