Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children
- 1 September 2003
- journal article
- Published by Springer Nature in Human Genetics
- Vol. 113 (4), 311-315
- https://doi.org/10.1007/s00439-003-0985-6
Abstract
Endothelial lipase (EL) is a new member of the triglyceride lipase family, the genes of which play a central role in dietary fat absorption, energy homeostasis, and plasma lipoprotein metabolism. One physiologic role of EL is thought to be hydrolysis of high-density lipoprotein (HDL) phospholipid, although the precise function of endothelial lipase has yet to be fully clarified. Furthermore, genetic variation in EL has been suggested to influence serum HDL-C levels. In the present study, we detected two common single nucleotide polymorphisms in the EL gene associated with serum HDL cholesterol levels in healthy school-aged children. Our data support the hypothesis that variations in the EL gene are one of the genetic determinants of serum HDL-C levels.Keywords
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