Oxidative Mechanisms of Tumour Tissue

Abstract

Rat sarcoma, rat carcinoma, and human mammary carcinoma contain abnormally small amounts of reduced glutathione, and are also deficient in cytochrome, the intracellular pigment described by Keilin, and believed to have a respiratory function. These tissues also show very slight activity in reducing added oxidized glutathione. The observations are believed to support the view of Warburg, that the cancer cell resembles an anaerobic rather than an aerobic organism.