Computed tomographic arteriography (CTA) of the liver performed during intra-arterial infusion of contrast material improved the detection of hepatic lesions [neoplastic and non-neoplastic] in 10 of 12 patients and was the only method that accurately determined the extent of disease in 6. This technique has significant advantages over conventional hepatic computed tomography with or without i.v. contrast enhancement, or selective hepatic angiography. It is recommended in the evaluation of selected patients, especially when there is a discrepancy between the findings obtained by other methods.