Estimates of heritability of plasma homocyst(e)ine levels in aging adult male twins
- 28 June 1991
- journal article
- Published by Wiley in Clinical Genetics
- Vol. 39 (6), 425-428
- https://doi.org/10.1111/j.1399-0004.1991.tb03053.x
Abstract
Plasma homocyst(e)ine level was determined for 96 identical (MZ) and 92 fraternal (DZ) adult male twins aged 59-69. There was no difference in mean between MZ (10.31 nmol/ml) and DZ (10.36 nmol/ml) twins. The intraclass correlation coefficient of the log-transformed homocyst(e)ine level in 43 complete MZ and 39 complete DZ pairs was 0.55 and 0.19, respectively. The MZ correlation was significantly (p less than 0.05) greater than the DZ correlation, suggesting that the level of plasma homocyst(e)ine is genetically influenced.Keywords
This publication has 24 references indexed in Scilit:
- Plasma homocyst(e)ine levels in men with premature coronary artery diseaseJournal of the American College of Cardiology, 1990
- Elevated plasma homocyst(e)ine concentration as a possible independent risk factor for stroke.Stroke, 1990
- Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease Effects of pyridoxine and folic acid treatmentAtherosclerosis, 1990
- Plasma sulfhydryl-containing amino acids in patients with cerebral infarction and in hypertensive subjectsAtherosclerosis, 1989
- Homocysteine and myocardial infarctionAtherosclerosis, 1988
- Higher total plasma homocysteine in vitamin B12 deficiency than in heterozygosity for homocystinuria due to cystathionine β-synthase deficiencyMetabolism, 1988
- Inherited Defects of Vitamin B MetabolismAnnual Review of Nutrition, 1987
- Heterozygosity for Homocystinuria in Premature Peripheral and Cerebral Occlusive Arterial DiseaseNew England Journal of Medicine, 1985
- Moderate homocysteinemia--a possible risk factor for arteriosclerotic cerebrovascular disease.Stroke, 1984
- THE NHLBI TWIN STUDY OF CARDIOVASCULAR DISEASE RISK FACTORS: METHODOLOGY AND SUMMARY OF RESULTSAmerican Journal of Epidemiology, 1977