Cell surface glycoprotein analysis: A diagnostic tool in human leukemias
- 15 March 1979
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 23 (3), 306-311
- https://doi.org/10.1002/ijc.2910230306
Abstract
We have radiolabelled surface glycoproteins of different types of leukemic cell. The labelled proteins were separated by polyacrylamide slab gel electrophoresis and visualized by fluorography. Surface glycoprotein patterns discriminatory for acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL). acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) were found. We conclude that the analysis of the surface glycoprotein profile provides a useful method for the classification of leukemic cells according to cell type and stage of differentiation.Keywords
This publication has 25 references indexed in Scilit:
- Chromosomes in Acute Non‐lymphocytic LeukaemiaBritish Journal of Haematology, 1978
- Pre-B-Cell LeukemiaNew England Journal of Medicine, 1978
- Surface glycoprotein patterns of normal and malignant human lymphoid cells. I. T cells, T blasts and leukemic T cell linesInternational Journal of Cancer, 1977
- Surface glycoprotein patterns of normal and malignant human lymphoid cells. II. B cells, B blasts and epstein‐barr virus (EBV)‐positive and ‐negative B lymphoid cell linesInternational Journal of Cancer, 1977
- Differentiation Linked Expression of p28,33 (Ia-like) Structures on Human Leukaemic CellsBritish Journal of Haematology, 1977
- Antisera to acute lymphoblastic leukemia cellsClinical Immunology and Immunopathology, 1975
- Enhancement of sheep red blood cell human lymphocyte rosette formation by the sulfhydryl compound 2-amino ethylisothiouronium bromideClinical Immunology and Immunopathology, 1975
- Antigens Specific for Human Lymphocytic and Myeloid Leukemia Cells: Detection by Nonhuman Primate AntiserumsScience, 1972
- Acute leukaemia: Cellular morphology, cytochemistry and fine structureClinics in Haematology, 1972
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970