A series of steroids was studied in the chicken using blood glucose and liver glycogen as indices of activity. In the chick, hydrocortisone, corticosterone and 11-dehydrocorticosterone produced glycogen deposition at doses of 25, 200 and 4000 [mu]g respectively. Very little deposition was apparent with doses of cortisone and 11 desoxy-17-OH-corticosterone as high as 16 mg. In the hen, hydrocortisone at 2.5 mg and corticosterone at 5 mg per day produced marked hyper-glycemia within 24 hours and throughout a 2 week period of treatment. Cortisone and 11-desoxycorticosterone had very little effect on blood glucose at daily doses of 40-50 mg. Testosterone, at 20-40 mg, appeared to depress blood glucose but this was apparently the result of a rise in hematocrit. In sharp contrast to the mammal, cortisone has virtually no glucocorticoid activity in the bird.