Presence of Anti‐c in the Serum of 42 Women Giving Birth to c Positive Babies: Serological and Clinical Findings1

Abstract

During routine ante-natal testing during the period 1953-73 anti-c was found in the serum of 63 women. Of them, 24 had received blood transfusion previously and of these 22 were multigravidae. In 39 women, pregnancies alone were responsible for the immunization. The anti-c titers of the 42 women giving birth to c positive babies showed that the probability of developing hemolytic disease increases with higher titers. But low titers by no means exclude the existence of such disease. Among the 42 c positive babies, 32 had a positive direct antiglobulin test. Some of the affected infants had a serious degree of hemolytic disease.