SOME NOTABLE DIFFERENCES BETWEEN THE RESULTS OF F. S. H.-ESTIMATIONS IN RAT HYPOPHYSES BY THE EXTRACTION AND IMPLANTATION METHODS RESPECTIVELY

Abstract

Comparison of the results of implantation and injection of pituitary extracts were studied to obtain data on the effect of sex hormones. When hypophyses from male rats treated with estradiol benzoate were homogenized and injected as an extract, less FSH-effect was obtained than with extracts of hypophyses from non-pretreated rats. There was only a slight difference when the hypophyses were left intact and implanted intraperitoneally. The high FSH-content of hypophyses from males treated with testosterone (1 mg daily) was unchanged with the homogenizing-extracting method, whereas implantation resulted in a diminished effect. The authors suggest that sex hormones have a separate effect on FSH-release. Estrogen appears to favor the diffusion of FSH and testosterone to impede it.