Distribution of chylomicrons and albumin in dog kidney

Abstract

Under specified experimental conditions the distribution space of labelled chylomicrons in the kidneywas 13.8 [plus or minus] 0.9 ml/100 g tissue. The assumption is supported that this provides a measure for the quantity of intravascular plasma constituents. Values for red blood cells and albumin distribution spaces were 5.2 [plus or minus] 0.6 and 20.2[plus or minus]1.0 ml/100 g tissue, respectively, in the whole kidney. The ratio of tissue hematocrit over simultaneous arterial hematocrit averaged 0.56. The extravascular albumin fraction amounted to about 31.0% of the total albumin in the whole kidney. A statistically significant correlation was demonstrated between osmotic urine/plasma (U/P) ratios (within the approximate limits of 0.6-1.8) and quantities of extravascular albumin in the medulla.