Antibacterial Action of Oxidized Spermine
- 1 November 1964
- journal article
- research article
- Published by Microbiology Society in Journal of General Microbiology
- Vol. 37 (2), 195-204
- https://doi.org/10.1099/00221287-37-2-195
Abstract
SUMMARY: Spermine oxidized by partially purified serum amine oxidase inhibited the growth of a variety of Gram-positive and Gram-negative bacteria. This inhibition of growth was not antagonized by calcium ion, and occurred over a wide pH range. Inactivation increased with time and temperature of incubation. The antibacterial action was abolished by treating oxidized spermine with sodium borohydride. Oxidized spermine inhibited protein synthesis as shown by incorporation of 14C-valine into cellular protein and by inhibition of β-galactosidase induction. Incorporation of 14C-uracil into the nucleic acids of Escherichia coli was not inhibited by oxidized spermine.Keywords
This publication has 8 references indexed in Scilit:
- Identification of the Aminoaldehydes Produced by the Oxidation of Spermine and Spermidine with Purified Plasma Amine OxidaseJournal of Biological Chemistry, 1964
- STABILIZATION OF PROTOPLASTS AND SPHEROPLASTS BY SPERMINE AND OTHER POLYAMINESJournal of Bacteriology, 1962
- Spermidine in the Bacterial CellJournal of General Microbiology, 1961
- The interaction of polynucleotides with metal ions, amino acids, and polyaminesBiochimica et Biophysica Acta, 1959
- Mechanism of the antibacterial action of spermineArchives of Biochemistry and Biophysics, 1959
- PHARMACOLOGY OF SPERMINE AND SPERMIDINE - SOME EFFECTS ON ANIMALS AND BACTERIA1956
- PURIFICATION OF AMINE OXIDASE FROM BEEF PLASMAJournal of Biological Chemistry, 1954
- THE EFFECT OF SPERMINE ON TUBERCLE BACILLIThe Journal of Experimental Medicine, 1952