Inducible and constitutive nucleoside-binding sites in Escherichia coli: differential inhibition by nucleoside analogues

Abstract

Constitutive and inducible nucleoside-binding sites on the surface of the cell s of E. coli B have different patterns of inhibition by nucleoside analogues. 1(β-D-Ribofuranosyl)-4-aminopyrimidine-6-one and isoguanosine preferentially inhibit the inducible binding sites while showdomycin and N⁴-dimethyl-cytidine interfere more strongly with the constitutive function.